Antibiotic-loaded bone cement and its widespread use: is it justified?

Key words: total hip arthroplasty, total knee arthroplasty, antibiotic-loaded bone cement, periprosthetic joint infection


Total hip and total knee arthroplasty (THA, TKA) are clinically efficacious and cost-effective interventions with numerous investigators reporting excellent long-term results in terms of reducing pain and improving function and quality of life in patients with debilitating hip and knee disease (Bozic et al., 2009-2010).
Along with a steady rise in the volume of joint prostheses implanted every year worldwide, there has been a rise in revision THA and TKA (OECD, 2014). Among the main reason for THA revision, infection accounts for 12 - 14.8% (NJR 2013; Bozic et al., 2009), while for the TKA the percentage is much higher, 22 - 25.2% (NJR 2013; Bozic et al., 2010). Periprosthetic joint infection (PJI) is therefore among the main reason for revision.


Можно ли получить качественный и эффективный костный цемент с антибиотиком самостоятельно?


По данным современной литературы, сегодня в медицинской практике достаточно широко используют костные цементы, в которые доктора самостоятельно добавляют антибиотик, для первичного и ревизионного эндопротезирования и даже для изготовления спейсеров (временных цементных имплантатов) в условиях операционной.


Vacuum-Mixing Significantly Changes Antibiotic Elution Characteristics of Commercially Available Antibiotic-Impregnated Bone Cements

Jill Meyer, PhD, Geoff Piller, MS, Carol A. Spiegel, PhD, Scott Hetzel, MS, and Matthew Squire, MD, MS
Investigation performed at the University of Wisconsin Hospitals and Clinics, Madison, Wisconsin


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